28 search results - page 4 / 6 » A rule-based framework for gene regulation pathways discover... |
RECOMB
2003
Springer
15 years 10 months ago
2003
Springer
We develop a new framework for inferring models of transcriptional regulation. The models in this approach, which we call physical models, are constructed on the basis of verifiab...
BMCBI
2007
14 years 9 months ago
2007
Background: Cell specific gene expression is largely regulated by different combinations of transcription factors that bind cis-elements in the upstream promoter sequence. However...
BMCBI
2005
14 years 9 months ago
2005
Background: MicroRNAs (miRNAs) are endogenous 21 to 23-nucleotide RNA molecules that regulate protein-coding gene expression in plants and animals via the RNA interference pathway...
88
Voted
BMCBI
2007
14 years 9 months ago
2007
Background: This work addresses the problem of detecting conserved transcription factor binding sites and in general regulatory regions through the analysis of sequences from homo...
66
Voted
BMCBI
2008
14 years 9 months ago
2008
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...