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112
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BMCBI
2006
137views more  BMCBI 2006»
15 years 19 days ago
A classification-based framework for predicting and analyzing gene regulatory response
Background: We have recently introduced a predictive framework for studying gene transcriptional regulation in simpler organisms using a novel supervised learning algorithm called...
Anshul Kundaje, Manuel Middendorf, Mihir Shah, Chr...
91
Voted
BMCBI
2006
130views more  BMCBI 2006»
15 years 19 days ago
MicroTar: predicting microRNA targets from RNA duplexes
Background: The accurate prediction of a comprehensive set of messenger RNAs (targets) regulated by animal microRNAs (miRNAs) remains an open problem. In particular, the predictio...
Rahul Thadani, Martti T. Tammi
129
Voted
BMCBI
2006
166views more  BMCBI 2006»
15 years 19 days ago
SEQOPTICS: a protein sequence clustering system
Background: Protein sequence clustering has been widely used as a part of the analysis of protein structure and function. In most cases single linkage or graph-based clustering al...
Yonghui Chen, Kevin D. Reilly, Alan P. Sprague, Zh...
102
Voted
BMCBI
2006
117views more  BMCBI 2006»
15 years 19 days ago
The Cluster Variation Method for Efficient Linkage Analysis on Extended Pedigrees
Background: Computing exact multipoint LOD scores for extended pedigrees rapidly becomes infeasible as the number of markers and untyped individuals increase. When markers are exc...
Cornelis A. Albers, Martijn A. R. Leisink, Hilbert...
106
Voted
BMCBI
2006
104views more  BMCBI 2006»
15 years 19 days ago
Semi-supervised discovery of differential genes
Background: Various statistical scores have been proposed for evaluating the significance of genes that may exhibit differential expression between two or more controlled conditio...
Shigeyuki Oba, Shin Ishii
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