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» A simple and fast heuristic for protein structure comparison
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DOCENG
2006
ACM
14 years 6 days ago
Fast and simple XML tree differencing by sequence alignment
With the advent of XML we have seen a renewed interest in methods for computing the difference between trees. Methods that include heuristic elements play an important role in pr...
Tancred Lindholm, Jaakko Kangasharju, Sasu Tarkoma
BMCBI
2007
107views more  BMCBI 2007»
13 years 6 months ago
Prediction of potential drug targets based on simple sequence properties
Background: During the past decades, research and development in drug discovery have attracted much attention and efforts. However, only 324 drug targets are known for clinical dr...
Qingliang Li, Luhua Lai
ALMOB
2008
82views more  ALMOB 2008»
13 years 6 months ago
Protein sequence and structure alignments within one framework
Background: Protein structure alignments are usually based on very different techniques to sequence alignments. We propose a method which treats sequence, structure and even combi...
Gundolf Schenk, Thomas Margraf, Andrew E. Torda
BMCBI
2006
137views more  BMCBI 2006»
13 years 6 months ago
A maximum likelihood framework for protein design
Background: The aim of protein design is to predict amino-acid sequences compatible with a given target structure. Traditionally envisioned as a purely thermodynamic question, thi...
Claudia L. Kleinman, Nicolas Rodrigue, Céci...
WABI
2001
Springer
142views Bioinformatics» more  WABI 2001»
13 years 10 months ago
Pattern Matching and Pattern Discovery Algorithms for Protein Topologies
We describe algorithms for pattern matching and pattern learning in TOPS diagrams (formal descriptions of protein topologies). These problems can be reduced to checking for subgrap...
Juris Viksna, David Gilbert