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BMCBI
2006
130views more  BMCBI 2006»
14 years 10 months ago
Spatial normalization of array-CGH data
Background: Array-based comparative genomic hybridization (array-CGH) is a recently developed technique for analyzing changes in DNA copy number. As in all microarray analyses, no...
Pierre Neuvial, Philippe Hupé, Isabel Brito...
BMCBI
2011
14 years 1 months ago
A Beta-Mixture Model for Dimensionality Reduction, Sample Classification and Analysis
Background: Patterns of genome-wide methylation vary between tissue types. For example, cancer tissue shows markedly different patterns from those of normal tissue. In this paper ...
Kirsti Laurila, Bodil Oster, Claus L. Andersen, Ph...
BMCBI
2010
124views more  BMCBI 2010»
14 years 10 months ago
Comparative analysis of acute and chronic corticosteroid pharmacogenomic effects in rat liver: Transcriptional dynamics and regu
Background: Comprehensively understanding corticosteroid pharmacogenomic effects is an essential step towards an insight into the underlying molecular mechanisms for both benefici...
Tung T. Nguyen, Richard R. Almon, Debra C. DuBois,...
CVPR
2007
IEEE
15 years 12 months ago
Two thresholds are better than one
The concept of the Bayesian optimal single threshold is a well established and widely used classification technique. In this paper, we prove that when spatial cohesion is assumed ...
Tao Zhang, Terrance E. Boult, R. C. Johnson
BMCBI
2008
125views more  BMCBI 2008»
14 years 10 months ago
MAID : An effect size based model for microarray data integration across laboratories and platforms
Background: Gene expression profiling has the potential to unravel molecular mechanisms behind gene regulation and identify gene targets for therapeutic interventions. As microarr...
Ivan Borozan, Limin Chen, Bryan Paeper, Jenny E. H...