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» A statistical model of skewed-associativity
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BMCBI
2010
119views more  BMCBI 2010»
15 years 24 days ago
A comparison of internal validation techniques for multifactor dimensionality reduction
Background: It is hypothesized that common, complex diseases may be due to complex interactions between genetic and environmental factors, which are difficult to detect in high-di...
Stacey J. Winham, Andrew J. Slater, Alison A. Mots...
114
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BMCBI
2008
174views more  BMCBI 2008»
15 years 24 days ago
Evolutionary approaches for the reverse-engineering of gene regulatory networks: A study on a biologically realistic dataset
Background: Inferring gene regulatory networks from data requires the development of algorithms devoted to structure extraction. When only static data are available, gene interact...
Cédric Auliac, Vincent Frouin, Xavier Gidro...
99
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BMCBI
2007
83views more  BMCBI 2007»
15 years 24 days ago
Identification of sequence motifs significantly associated with antisense activity
Background: Predicting the suppression activity of antisense oligonucleotide sequences is the main goal of the rational design of nucleic acids. To create an effective predictive ...
Kyle A. McQuisten, Andrew S. Peek
102
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BMCBI
2008
115views more  BMCBI 2008»
15 years 24 days ago
Probe signal correction for differential methylation hybridization experiments
Background: Non-biological signal (or noise) has been the bane of microarray analysis. Hybridization effects related to probe-sequence composition and DNA dye-probe interactions h...
Dustin P. Potter, Pearlly Yan, Tim Hui-Ming Huang,...
115
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BMCBI
2008
149views more  BMCBI 2008»
15 years 24 days ago
Evolution of biological sequences implies an extreme value distribution of type I for both global and local pairwise alignment s
Background: Confidence in pairwise alignments of biological sequences, obtained by various methods such as Blast or Smith-Waterman, is critical for automatic analyses of genomic d...
Olivier Bastien, Eric Maréchal