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» A structural alignment kernel for protein structures
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ENGL
2008
121views more  ENGL 2008»
14 years 9 months ago
Prediction of Protein-Protein Interactions Using Pairwise Alignment and Inter-Domain Linker Region
One of the central problems in modern biology is to identify the complete set of interactions among the proteins in a cell. The structural interaction of proteins and their domains...
Nazar Zaki
84
Voted
CIBCB
2005
IEEE
15 years 3 months ago
Toward Protein Structure Analysis with Self-Organizing Maps
- Establishing structure-function relationships on the proteomic scale is a unique challenge faced by bioinformatics and molecular biosciences. Large protein families represent nat...
Lutz Hamel, Gongqin Sun, Jing Zhang
87
Voted
BMCBI
2007
140views more  BMCBI 2007»
14 years 9 months ago
Accurate prediction of protein secondary structure and solvent accessibility by consensus combiners of sequence and structure in
Background: Structural properties of proteins such as secondary structure and solvent accessibility contribute to three-dimensional structure prediction, not only in the ab initio...
Gianluca Pollastri, Alberto J. M. Martin, Catherin...
BMCBI
2007
142views more  BMCBI 2007»
14 years 9 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
BMCBI
2004
120views more  BMCBI 2004»
14 years 9 months ago
An approach to large scale identification of non-obvious structural similarities between proteins
Background: A new sequence independent bioinformatics approach allowing genome-wide search for proteins with similar three dimensional structures has been developed. By utilizing ...
Artem Cherkasov, Steven J. M. Jones