One of the central problems in modern biology is to identify the complete set of interactions among the proteins in a cell. The structural interaction of proteins and their domains...
- Establishing structure-function relationships on the proteomic scale is a unique challenge faced by bioinformatics and molecular biosciences. Large protein families represent nat...
Background: Structural properties of proteins such as secondary structure and solvent accessibility contribute to three-dimensional structure prediction, not only in the ab initio...
Gianluca Pollastri, Alberto J. M. Martin, Catherin...
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Background: A new sequence independent bioinformatics approach allowing genome-wide search for proteins with similar three dimensional structures has been developed. By utilizing ...