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» A structural alignment kernel for protein structures
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BIBE
2007
IEEE
128views Bioinformatics» more  BIBE 2007»
15 years 4 months ago
QOMA2: Optimizing the alignment of many sequences
Abstract—We consider the problem of aligning multiple protein sequences with the goal of maximizing the SP (Sum-of-Pairs) score, when the number of sequences is large. The QOMA (...
Xu Zhang, Tamer Kahveci
BMCBI
2005
198views more  BMCBI 2005»
14 years 9 months ago
Clustering protein sequences with a novel metric transformed from sequence similarity scores and sequence alignments with neural
Background: The sequencing of the human genome has enabled us to access a comprehensive list of genes (both experimental and predicted) for further analysis. While a majority of t...
Qicheng Ma, Gung-Wei Chirn, Richard Cai, Joseph D....
BIOINFORMATICS
2005
71views more  BIOINFORMATICS 2005»
14 years 9 months ago
Semi-supervised protein classification using cluster kernels
A key issue in supervised protein classification is the representation of input sequences of amino acids. Recent work using string kernels for protein data has achieved state-of-t...
Jason Weston, Christina S. Leslie, Eugene Ie, Deng...
CIBCB
2006
IEEE
15 years 3 months ago
Prediction of the Number of Helices for the Twilight Zone Proteins
– Protein structure prediction is one of the core research areas in bioinformatics. This paper addresses the protein secondary structure prediction problem for the twilight zone ...
Kanaka Durga Kedarisetti, Ke Chen, Aashima Kapoor,...
CPM
1993
Springer
154views Combinatorics» more  CPM 1993»
15 years 1 months ago
On Suboptimal Alignments of Biological Sequences
It is widely accepted that the optimal alignment between a pair of proteins or nucleic acid sequences that minimizes the edit distance may not necessarily re ect the correct biolog...
Dalit Naor, Douglas L. Brutlag