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» A structural alignment kernel for protein structures
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BIB
2006
141views more  BIB 2006»
14 years 9 months ago
Statistical significance in biological sequence analysis
One of the major goals of computational sequence analysis is to find sequence similarities, which could serve as evidence of structural and functional conservation, as well as of ...
Alexander Yu. Mitrophanov, Mark Borodovsky
ISMB
1997
14 years 11 months ago
Bayesian Adaptive Alignment and Inference
Sequencealignmentwithoutthe specification of gap penaltiesor a scoringmatrixis attainedbyusing Bayesianinferenceanda recursivealgorithm.Thisprocedure’srecursivealgorithmsumsover...
Jun Zhu, Jun S. Liu, Charles E. Lawrence
98
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BMCBI
2006
139views more  BMCBI 2006»
14 years 9 months ago
Improvement in accuracy of multiple sequence alignment using novel group-to-group sequence alignment algorithm with piecewise li
Background: Multiple sequence alignment (MSA) is a useful tool in bioinformatics. Although many MSA algorithms have been developed, there is still room for improvement in accuracy...
Shinsuke Yamada, Osamu Gotoh, Hayato Yamana
92
Voted
NAR
2006
119views more  NAR 2006»
14 years 9 months ago
HHsenser: exhaustive transitive profile search using HMM-HMM comparison
HHsenser is the first server to offer exhaustive intermediate profile searches, which it combines with pairwise comparison of hidden Markov models. Starting from a single protein ...
Johannes Söding, Michael Remmert, Andreas Bie...
67
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BMCBI
2008
176views more  BMCBI 2008»
14 years 9 months ago
H2r: Identification of evolutionary important residues by means of an entropy based analysis of multiple sequence alignments
Background: A multiple sequence alignment (MSA) generated for a protein can be used to characterise residues by means of a statistical analysis of single columns. In addition to t...
Rainer Merkl, Matthias Zwick