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BMCBI
2008
104views more  BMCBI 2008»
14 years 10 months ago
Evolutionary Pareto-optimization of stably folding peptides
Background: As a rule, peptides are more flexible and unstructured than proteins with their substantial stabilizing hydrophobic cores. Nevertheless, a few stably folding peptides ...
Wolfram Gronwald, Tim Hohm, Daniel Hoffmann
105
Voted
CP
2001
Springer
15 years 2 months ago
A CLP Approach to the Protein Side-Chain Placement Problem
Abstract. Selecting conformations for side-chains is an important subtask in building three-dimensional protein models. Side-chain placement is a difficult problem because of the l...
Martin T. Swain, Graham J. L. Kemp
COGSCI
2008
74views more  COGSCI 2008»
14 years 10 months ago
Optimal Predictions in Everyday Cognition: The Wisdom of Individuals or Crowds?
Griffiths and Tenenbaum (2006) asked individuals to make predictions about the duration or extent of everyday events (e.g., cake baking times), and reported that predictions were ...
Michael C. Mozer, Harold Pashler, Hadjar Homaei
ICML
2007
IEEE
15 years 11 months ago
An integrated approach to feature invention and model construction for drug activity prediction
We present a new machine learning approach for 3D-QSAR, the task of predicting binding affinities of molecules to target proteins based on 3D structure. Our approach predicts bind...
David Page, Jesse Davis, Soumya Ray, Vítor ...
BMCBI
2010
118views more  BMCBI 2010»
14 years 10 months ago
Computing H/D-Exchange rates of single residues from data of proteolytic fragments
Background: Protein conformation and protein/protein interaction can be elucidated by solution-phase Hydrogen/ Deuterium exchange (sHDX) coupled to high-resolution mass analysis o...
Ernst Althaus, Stefan Canzar, Carsten Ehrler, Mark...