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RECOMB
2006
Springer
16 years 1 months ago
De Novo Signaling Pathway Predictions Based on Protein-Protein Interaction, Targeted Therapy and Protein Microarray Analysis
Abstract. Mapping intra-cellular signaling networks is a critical step in developing an understanding of and treatments for many devastating diseases. The predominant ways of disco...
Derek A. Ruths, Jen-Te Tseng, Luay Nakhleh, Prahla...
BMCBI
2007
101views more  BMCBI 2007»
15 years 1 months ago
Relationship between insertion/deletion (indel) frequency of proteins and essentiality
Background: In a previous study, we demonstrated that some essential proteins from pathogenic organisms contained sizable insertions/deletions (indels) when aligned to human prote...
Simon K. Chan, Michael Hsing, Fereydoun Hormozdiar...
ISMB
2000
15 years 2 months ago
Genomic Fold Assignment and Rational Modeling of Proteins of Biological Interest
The first available genome of a multicellular organism, C. elegans, was used as a test case for protein fold assignment using PSI-BLAST, followed by rational structure modeling an...
J. Michael Sauder, Roland L. Dunbrack Jr.
AE
2005
Springer
15 years 6 months ago
An Enhanced Genetic Algorithm for Protein Structure Prediction Using the 2D Hydrophobic-Polar Model
This paper presents an enhanced genetic algorithm for the protein structure prediction problem. A new fitness function, that uses the concept of radius of gyration, is proposed. Al...
Heitor S. Lopes, Marcos P. Scapin
ICPR
2006
IEEE
16 years 2 months ago
Protein Fold Recognition using a Structural Hidden Markov Model
Protein fold recognition has been the focus of computational biologists for many years. In order to map a protein primary structure to its correct 3D fold, we introduce in this pa...
Djamel Bouchaffra, Jun Tan