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ATAL
2004
Springer
15 years 7 months ago
About Engineering Complex Systems: Multiscale Analysis and Evolutionary Engineering
Abstract. We describe an analytic approach, multiscale analysis, that can demonstrate the fundamental limitations of decomposition based engineering for the development of highly c...
Yaneer Bar-Yam
BIRTHDAY
2009
Springer
15 years 8 months ago
Reasoning About Alternative Requirements Options
This paper elaborates on some of the fundamental contributions made by John Mylopoulos in the area of Requirements Engineering. We specifically focus on the use of goal models and ...
Axel van Lamsweerde
BMCBI
2010
98views more  BMCBI 2010»
15 years 1 months ago
An optimized TOPS+ comparison method for enhanced TOPS models
nd: Although methods based on highly abstract descriptions of protein structures, such as VAST and TOPS, can perform very fast protein structure comparison, the results can lack a...
Mallika Veeramalai, David Gilbert, Gabriel Valient...
RECOMB
2007
Springer
16 years 1 months ago
A Feature-Based Approach to Modeling Protein-DNA Interactions
Transcription factor (TF) binding to its DNA target site is a fundamental regulatory interaction. The most common model used to represent TF binding specificities is a position spe...
Eilon Sharon, Eran Segal
BMCBI
2007
190views more  BMCBI 2007»
15 years 1 months ago
Discriminative motif discovery in DNA and protein sequences using the DEME algorithm
Background: Motif discovery aims to detect short, highly conserved patterns in a collection of unaligned DNA or protein sequences. Discriminative motif finding algorithms aim to i...
Emma Redhead, Timothy L. Bailey