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98
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BMCBI
2008
130views more  BMCBI 2008»
15 years 27 days ago
FAF-Drugs2: Free ADME/tox filtering tool to assist drug discovery and chemical biology projects
Background: Drug discovery and chemical biology are exceedingly complex and demanding enterprises. In recent years there are been increasing awareness about the importance of pred...
David Lagorce, Olivier Sperandio, Hervé Gal...
87
Voted
BMCBI
2008
122views more  BMCBI 2008»
15 years 27 days ago
Effects of dependence in high-dimensional multiple testing problems
Background: We consider effects of dependence among variables of high-dimensional data in multiple hypothesis testing problems, in particular the False Discovery Rate (FDR) contro...
Kyung In Kim, Mark A. van de Wiel
70
Voted
BMCBI
2008
78views more  BMCBI 2008»
15 years 27 days ago
Genome Environment Browser (GEB): a dynamic browser for visualising high-throughput experimental data in the context of genome f
Background: There is accumulating evidence that the milieu of repeat elements and other nongenic sequence features at a given chromosomal locus, here defined as the genome environ...
Derek Huntley, Y. Amy Tang, Tatyana B. Nesterova, ...
127
Voted
BMCBI
2008
147views more  BMCBI 2008»
15 years 27 days ago
Transmembrane helix prediction using amino acid property features and latent semantic analysis
Background: Prediction of transmembrane (TM) helices by statistical methods suffers from lack of sufficient training data. Current best methods use hundreds or even thousands of f...
Madhavi Ganapathiraju, Narayanas Balakrishnan, Raj...
103
Voted
BMCBI
2008
135views more  BMCBI 2008»
15 years 27 days ago
Ab-origin: an enhanced tool to identify the sourcing gene segments in germline for rearranged antibodies
Background: In the adaptive immune system, variable regions of immunoglobulin (IG) are encoded by random recombination of variable (V), diversity (D), and joining (J) gene segment...
Xiaojing Wang, Di Wu, SiYuan Zheng, Jing Sun, Lin ...
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