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BMCBI
2010
88views more  BMCBI 2010»
15 years 4 months ago
Proteome scanning to predict PDZ domain interactions using support vector machines
Background: PDZ domains mediate protein-protein interactions involved in important biological processes through the recognition of short linear motifs in their target proteins. Tw...
Shirley Hui, Gary D. Bader
BMCBI
2010
139views more  BMCBI 2010»
15 years 4 months ago
CMASA: an accurate algorithm for detecting local protein structural similarity and its application to enzyme catalytic site anno
Background: The rapid development of structural genomics has resulted in many "unknown function" proteins being deposited in Protein Data Bank (PDB), thus, the functiona...
Gong-Hua Li, Jing-Fei Huang
BMCBI
2010
124views more  BMCBI 2010»
15 years 4 months ago
Estimating time since infection in early homogeneous HIV-1 samples using a poisson model
Background: The occurrence of a genetic bottleneck in HIV sexual or mother-to-infant transmission has been well documented. This results in a majority of new infections being homo...
Elena E. Giorgi, Bob Funkhouser, Gayathri Athreya,...
BMCBI
2010
186views more  BMCBI 2010»
15 years 4 months ago
Knowledge-based biomedical word sense disambiguation: comparison of approaches
Background: Word sense disambiguation (WSD) algorithms attempt to select the proper sense of ambiguous terms in text. Resources like the UMLS provide a reference thesaurus to be u...
Antonio Jimeno Yepes, Alan R. Aronson
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BMCBI
2008
79views more  BMCBI 2008»
15 years 4 months ago
A high-throughput pipeline for designing microarray-based pathogen diagnostic assays
Background: We present a methodology for high-throughput design of oligonucleotide fingerprints for microarray-based pathogen diagnostic assays. The oligonucleotide fingerprints, ...
Ravi Vijaya Satya, Nela Zavaljevski, Kamal Kumar, ...
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