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123
Voted
BMCBI
2006
15 years 3 months ago
2006
Background: Two-dimensional gel electrophoresis (2DE) is a powerful technique to examine post-translational modifications of complexly modulated proteins. Currently, spot detectio...
120
Voted
BMCBI
2006
15 years 3 months ago
2006
Background: In a microarray experiment the difference in expression between genes on the same slide is up to 103 fold or more. At low expression, even a small error in the estimat...
128
Voted
BMCBI
2006
15 years 3 months ago
2006
Background: The design of oligonucleotides and PCR primers for studying large genomes is complicated by the redundancy of sequences. The eukaryotic genomes are particularly diffic...
133
Voted
BMCBI
2006
15 years 3 months ago
2006
Background: The imprint of natural selection on gene sequences is often difficult to detect. A plethora of methods have been devised to detect genetic changes due to selective pro...
112
Voted
BMCBI
2006
15 years 3 months ago
2006
Background: Protein phosphorylation is an extremely important mechanism of cellular regulation. A large-scale study of phosphoproteins in a whole-cell lysate of Saccharomyces cere...