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BMCBI
2010
153views more  BMCBI 2010»
15 years 26 days ago
Challenges in microarray class discovery: a comprehensive examination of normalization, gene selection and clustering
Background: Cluster analysis, and in particular hierarchical clustering, is widely used to extract information from gene expression data. The aim is to discover new classes, or su...
Eva Freyhult, Mattias Landfors, Jenny Önskog,...
BMCBI
2007
144views more  BMCBI 2007»
15 years 26 days ago
Application of amino acid occurrence for discriminating different folding types of globular proteins
Background: Predicting the three-dimensional structure of a protein from its amino acid sequence is a long-standing goal in computational/molecular biology. The discrimination of ...
Y.-h. Taguchi, M. Michael Gromiha
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BMCBI
2007
97views more  BMCBI 2007»
15 years 26 days ago
Relating destabilizing regions to known functional sites in proteins
Background: Most methods for predicting functional sites in protein 3D structures, rely on information on related proteins and cannot be applied to proteins with no known relative...
Benoit H. Dessailly, Marc F. Lensink, Shoshana J. ...
BMCBI
2008
136views more  BMCBI 2008»
15 years 26 days ago
GPAT: Retrieval of genomic annotation from large genomic position datasets
Background: Recent genome wide transcription factor binding site or chromatin modification mapping analysis techniques, such as chromatin immunoprecipitation (ChIP) linked to DNA ...
Arnaud Krebs, Mattia Frontini, Làszlò...
BMCBI
2008
93views more  BMCBI 2008»
15 years 26 days ago
Homology modelling of protein-protein complexes: a simple method and its possibilities and limitations
Background: Structure-based computational methods are needed to help identify and characterize protein-protein complexes and their function. For individual proteins, the most succ...
Guillaume Launay, Thomas Simonson
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