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» Adversarial Sequence Prediction
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BMCBI
2008
142views more  BMCBI 2008»
15 years 5 months ago
Strategies for measuring evolutionary conservation of RNA secondary structures
Background: Evolutionary conservation of RNA secondary structure is a typical feature of many functional non-coding RNAs. Since almost all of the available methods used for predic...
Andreas R. Gruber, Stephan H. F. Bernhart, Ivo L. ...
BMCBI
2006
116views more  BMCBI 2006»
15 years 5 months ago
Optimized mixed Markov models for motif identification
Background: Identifying functional elements, such as transcriptional factor binding sites, is a fundamental step in reconstructing gene regulatory networks and remains a challengi...
Weichun Huang, David M. Umbach, Uwe Ohler, Leping ...
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BMCBI
2005
60views more  BMCBI 2005»
15 years 5 months ago
PHACCS, an online tool for estimating the structure and diversity of uncultured viral communities using metagenomic information
Background: Phages, viruses that infect prokaryotes, are the most abundant microbes in the world. A major limitation to studying these viruses is the difficulty of cultivating the...
Florent Angly, Beltran Rodriguez-Brito, David Bang...
RECOMB
2008
Springer
16 years 6 months ago
Constructing Treatment Portfolios Using Affinity Propagation
A key problem of interest to biologists and medical researchers is the selection of a subset of queries or treatments that provide maximum utility for a population of targets. For ...
Delbert Dueck, Brendan J. Frey, Nebojsa Jojic, Vla...
IPPS
2006
IEEE
15 years 11 months ago
A method to improve structural modeling based on conserved domain clusters
—Homology modeling requires an accurate alignment between a query sequence and its homologs with known three-dimensional (3D) information. Current structural modeling techniques ...
Fa Zhang, Lin Xu, Bo Yuan