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160
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BMCBI
2008
15 years 6 months ago
2008
Background: The number of protein targets with a known or predicted tri-dimensional structure and of drug-like chemical compounds is growing rapidly and so is the need for new the...
146
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BMCBI
2007
2007
A high-accuracy consensus map of yeast protein complexes reveals modular nature of gene essentiality
15 years 6 months ago
Background: Identifying all protein complexes in an organism is a major goal of systems biology. In the past 18 months, the results of two genome-scale tandem affinity purificatio...
177
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BMCBI
2008
15 years 6 months ago
2008
Background: Current sequencing technologies give access to sequence information for genomes and metagenomes at a tremendous speed. Subsequent data processing is mainly performed b...
163
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BMCBI
2008
15 years 6 months ago
2008
Background: Sequence searches are routinely employed to detect and annotate related proteins. However, a rapid growth of databases necessitates a frequent repetition of sequence s...
152
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BMCBI
2008
15 years 6 months ago
2008
Background: Single Nucleotide Polymorphisms (SNPs) are the most abundant form of genomic variation and can cause phenotypic differences between individuals, including diseases. Ba...