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BMCBI
2005
113views more  BMCBI 2005»
15 years 22 days ago
Normal uniform mixture differential gene expression detection for cDNA microarrays
Background: One of the primary tasks in analysing gene expression data is finding genes that are differentially expressed in different samples. Multiple testing issues due to the ...
Nema Dean, Adrian E. Raftery
93
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BMCBI
2005
62views more  BMCBI 2005»
15 years 22 days ago
Differences in codon bias cannot explain differences in translational power among microbes
Background: Translational power is the cellular rate of protein synthesis normalized to the biomass invested in translational machinery. Published data suggest a previously unreco...
Les Dethlefsen, Thomas M. Schmidt
125
Voted
BMCBI
2005
147views more  BMCBI 2005»
15 years 22 days ago
GATA: a graphic alignment tool for comparative sequence analysis
Background: Several problems exist with current methods used to align DNA sequences for comparative sequence analysis. Most dynamic programming algorithms assume that conserved se...
David A. Nix, Michael B. Eisen
108
Voted
BMCBI
2005
125views more  BMCBI 2005»
15 years 22 days ago
Multiple sequence alignments of partially coding nucleic acid sequences
Background: High quality sequence alignments of RNA and DNA sequences are an important prerequisite for the comparative analysis of genomic sequence data. Nucleic acid sequences, ...
Roman R. Stocsits, Ivo L. Hofacker, Claudia Fried,...
79
Voted
BMCBI
2005
94views more  BMCBI 2005»
15 years 22 days ago
A method for finding single-nucleotide polymorphisms with allele frequencies in sequences of deep coverage
Background: The allele frequencies of single-nucleotide polymorphisms (SNPs) are needed to select an optimal subset of common SNPs for use in association studies. Sequence-based m...
Jianmin Wang, Xiaoqiu Huang
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