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» Alternating Refinement Relations
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128
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BMCBI
2006
153views more  BMCBI 2006»
15 years 15 days ago
Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments
Background: The small sample sizes often used for microarray experiments result in poor estimates of variance if each gene is considered independently. Yet accurately estimating v...
Maureen A. Sartor, Craig R. Tomlinson, Scott C. We...
89
Voted
BMCBI
2006
100views more  BMCBI 2006»
15 years 15 days ago
STAR: predicting recombination sites from amino acid sequence
Background: Designing novel proteins with site-directed recombination has enormous prospects. By locating effective recombination sites for swapping sequence parts, the probabilit...
Denis C. Bauer, Mikael Bodén, Ricarda Thier...
133
Voted
BMCBI
2006
194views more  BMCBI 2006»
15 years 15 days ago
Novel metaheuristic for parameter estimation in nonlinear dynamic biological systems
Background: We consider the problem of parameter estimation (model calibration) in nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and multi-m...
Maria Rodriguez-Fernandez, Jose A. Egea, Julio R. ...
104
Voted
BMCBI
2006
116views more  BMCBI 2006»
15 years 15 days ago
Optimized mixed Markov models for motif identification
Background: Identifying functional elements, such as transcriptional factor binding sites, is a fundamental step in reconstructing gene regulatory networks and remains a challengi...
Weichun Huang, David M. Umbach, Uwe Ohler, Leping ...
100
Voted
CCE
2006
15 years 15 days ago
State-of-the-art review of optimization methods for short-term scheduling of batch processes
There has been significant progress in the area of short-term scheduling of batch processes, including the solution of industrial-sized problems, in the last 20 years. The main go...
Carlos A. Méndez, Jaime Cerdá, Ignac...