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BMCBI
2007
145views more  BMCBI 2007»
15 years 5 months ago
The utility of MAS5 expression summary and detection call algorithms
Background: Used alone, the MAS5.0 algorithm for generating expression summaries has been criticized for high False Positive rates resulting from exaggerated variance at low inten...
Stuart D. Pepper, Emma K. Saunders, Laura E. Edwar...
BMCBI
2007
144views more  BMCBI 2007»
15 years 5 months ago
Assessing the ability of sequence-based methods to provide functional insight within membrane integral proteins: a case study an
Background: Efforts to predict functional sites from globular proteins is increasingly common; however, the most successful of these methods generally require structural insight. ...
Dennis R. Livesay, Patrick D. Kidd, Sepehr Eskanda...
BMCBI
2007
147views more  BMCBI 2007»
15 years 5 months ago
Bias in random forest variable importance measures: Illustrations, sources and a solution
Variable importance measures for random forests have been receiving increased attention as a means of variable selection in many classification tasks in bioinformatics and relate...
Carolin Strobl, Anne-Laure Boulesteix, Achim Zeile...
BMCBI
2007
113views more  BMCBI 2007»
15 years 5 months ago
Statistical tools for transgene copy number estimation based on real-time PCR
Background: As compared with traditional transgene copy number detection technologies such as Southern blot analysis, real-time PCR provides a fast, inexpensive and high-throughpu...
Joshua S. Yuan, Jason N. Burris, Nathan R. Stewart...
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BMCBI
2007
106views more  BMCBI 2007»
15 years 5 months ago
Simultaneous identification of long similar substrings in large sets of sequences
Background: Sequence comparison faces new challenges today, with many complete genomes and large libraries of transcripts known. Gene annotation pipelines match these sequences in...
Jürgen Kleffe, Friedrich Möller, Burghar...
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