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» An Approach for Method Reengineering
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BMCBI
2006
117views more  BMCBI 2006»
15 years 4 months ago
The Cluster Variation Method for Efficient Linkage Analysis on Extended Pedigrees
Background: Computing exact multipoint LOD scores for extended pedigrees rapidly becomes infeasible as the number of markers and untyped individuals increase. When markers are exc...
Cornelis A. Albers, Martijn A. R. Leisink, Hilbert...
154
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BMCBI
2007
174views more  BMCBI 2007»
15 years 5 months ago
Normalization method for metabolomics data using optimal selection of multiple internal standards
Background: Success of metabolomics as the phenotyping platform largely depends on its ability to detect various sources of biological variability. Removal of platform-specific so...
Marko Sysi-Aho, Mikko Katajamaa, Laxman Yetukuri, ...
BMCBI
2005
94views more  BMCBI 2005»
15 years 4 months ago
A method for finding single-nucleotide polymorphisms with allele frequencies in sequences of deep coverage
Background: The allele frequencies of single-nucleotide polymorphisms (SNPs) are needed to select an optimal subset of common SNPs for use in association studies. Sequence-based m...
Jianmin Wang, Xiaoqiu Huang
BMCBI
2008
96views more  BMCBI 2008»
15 years 5 months ago
Use of normalization methods for analysis of microarrays containing a high degree of gene effects
Background: High-throughput microarrays are widely used to study gene expression across tissues and developmental stages. Analysis of gene expression data is challenging in these ...
Terri T. Ni, William J. Lemon, Yu Shyr, Tao P. Zho...
181
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SIAMSC
2011
85views more  SIAMSC 2011»
14 years 7 months ago
Refinement and Connectivity Algorithms for Adaptive Discontinuous Galerkin Methods
Abstract. Adaptive multiscale methods are among the many effective techniques for the numerical solution of partial differential equations. Efficient grid management is an import...
Kolja Brix, Ralf Massjung, Alexander Voss