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» An Evolutionary Approach for Molecular Docking
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BMCBI
2007
162views more  BMCBI 2007»
13 years 6 months ago
Three-Dimensional Phylogeny Explorer: Distinguishing paralogs, lateral transfer, and violation of "molecular clock" assumption w
Background: Construction and interpretation of phylogenetic trees has been a major research topic for understanding the evolution of genes. Increases in sequence data and complexi...
Namshin Kim, Christopher Lee
GECCO
2005
Springer
189views Optimization» more  GECCO 2005»
13 years 11 months ago
Molecular programming: evolving genetic programs in a test tube
We present a molecular computing algorithm for evolving DNA-encoded genetic programs in a test tube. The use of synthetic DNA molecules combined with biochemical techniques for va...
Byoung-Tak Zhang, Ha-Young Jang
BMCBI
2006
122views more  BMCBI 2006»
13 years 6 months ago
A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks
Background:Receptors and scaffold proteins possess a number of distinct domains and bind multiple partners. A common problem in modeling signaling systems arises from a combinator...
Holger Conzelmann, Julio Saez-Rodriguez, Thomas Sa...
BMCBI
2005
102views more  BMCBI 2005»
13 years 6 months ago
Modelling the interaction of steroid receptors with endocrine disrupting chemicals
Background: The organic polychlorinated compounds like dichlorodiphenyltrichloroethane with its metabolites and polychlorinated biphenyls are a class of highly persistent environm...
Pasqualina D'Ursi, Erika Salvi, Paola Fossa, Lucia...
BMCBI
2008
130views more  BMCBI 2008»
13 years 6 months ago
IDEA: Interactive Display for Evolutionary Analyses
Background: The availability of complete genomic sequences for hundreds of organisms promises to make obtaining genome-wide estimates of substitution rates, selective constraints ...
Amy Egan, Anup Mahurkar, Jonathan Crabtree, Jonath...