Background: Structure-dependent substitution matrices increase the accuracy of sequence alignments when the 3D structure of one sequence is known, and are successful e.g. in fold ...
The typical mode for querying in an image content-based information system is query-by-example, which allows the user to provide an image as a query and to search for similar imag...
Background: Experimentally determined protein structures may contain errors and require validation. Conformational criteria based on the Ramachandran plot are mainly used to disti...
Background: Data from metabolomic studies are typically complex and high-dimensional. Principal component analysis (PCA) is currently the most widely used statistical technique fo...
Gift Nyamundanda, Lorraine Brennan, Isobel Claire ...
: The traditional latent class analysis (LCA) uses a mixture model with binary responses on each subject that are independent conditional on cluster membership. However, in many pr...