Background: Protein function is often dependent on subsets of solvent-exposed residues that may exist in a similar three-dimensional configuration in non homologous proteins thus ...
Background: Numerous functional genomics approaches have been developed to study the model organism yeast, Saccharomyces cerevisiae, with the aim of systematically understanding t...
Negar Memarian, Matthew Jessulat, Javad Alirezaie,...
— Software is often constructed using a layered approach to encapsulate various functionality in corresponding layers. Individual requirements of each layer demand layer specifi...
Michael Thonhauser, Gernot Schmoelzer, Christian K...
Background: Accurate identification of novel, functional noncoding (nc) RNA features in genome sequence has proven more difficult than for exons. Current algorithms identify and s...
Tomas Babak, Benjamin J. Blencowe, Timothy R. Hugh...
We propose an unsupervised methodology using independent component analysis (ICA) to cluster genes from DNA microarray data. Based on an ICA mixture model of genomic expression pa...