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BMCBI
2010
132views more  BMCBI 2010»
15 years 2 months ago
Protein network prediction and topological analysis in Leishmania major as a tool for drug target selection
Background: Leishmaniasis is a virulent parasitic infection that causes a worldwide disease burden. Most treatments have toxic side-effects and efficacy has decreased due to the e...
Andrés F. Flórez, Daeui Park, Jong B...
GECCO
2010
Springer
187views Optimization» more  GECCO 2010»
15 years 5 months ago
Benchmarking the (1, 4)-CMA-ES with mirrored sampling and sequential selection on the noisy BBOB-2010 testbed
The Covariance-Matrix-Adaptation Evolution-Strategy (CMA-ES) is a robust stochastic search algorithm for optimizing functions defined on a continuous search space RD . Recently, ...
Anne Auger, Dimo Brockhoff, Nikolaus Hansen
BMCBI
2010
105views more  BMCBI 2010»
15 years 2 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
ICIC
2007
Springer
15 years 8 months ago
Evolutionary Ensemble for In Silico Prediction of Ames Test Mutagenicity
Driven by new regulations and animal welfare, the need to develop in silico models has increased recently as alternative approaches to safety assessment of chemicals without animal...
Huanhuan Chen, Xin Yao
BMCBI
2006
165views more  BMCBI 2006»
15 years 1 months ago
Improving the quality of protein structure models by selecting from alignment alternatives
Background: In the area of protein structure prediction, recently a lot of effort has gone into the development of Model Quality Assessment Programs (MQAPs). MQAPs distinguish hig...
Ingolf Sommer, Stefano Toppo, Oliver Sander, Thoma...