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BMCBI
2002
214views more  BMCBI 2002»
14 years 10 months ago
Automated modelling of signal transduction networks
Background: Intracellular signal transduction is achieved by networks of proteins and small molecules that transmit information from the cell surface to the nucleus, where they ul...
Martin Steffen, Allegra Petti, John Aach, Patrik D...
BMCBI
2007
169views more  BMCBI 2007»
14 years 10 months ago
Transcriptional regulatory network refinement and quantification through kinetic modeling, gene expression microarray data and i
Background: Gene expression microarray and other multiplex data hold promise for addressing the challenges of cellular complexity, refined diagnoses and the discovery of well-targ...
Abdallah Sayyed-Ahmad, Kagan Tuncay, Peter J. Orto...
BMCBI
2008
134views more  BMCBI 2008»
14 years 10 months ago
Clustering cancer gene expression data: a comparative study
Background The use of clustering methods for the discovery of cancer subtypes has drawn a great deal of attention in the scientific community. While bioinformaticians have propose...
Marcílio Carlos Pereira de Souto, Ivan G. C...
BMCBI
2007
102views more  BMCBI 2007»
14 years 10 months ago
Multivariate Analysis and Visualization of Splicing Correlations in Single-Gene Transcriptomes
Background: RNA metabolism, through 'combinatorial splicing', can generate enormous structural diversity in the proteome. Alternative domains may interact, however, with...
Mark C. Emerick, Giovanni Parmigiani, William S. A...
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ECCB
2005
IEEE
15 years 3 months ago
A query language for biological networks
Many areas of modern biology are concerned with the management, storage, visualization, comparison, and analysis of networks. For instance, networks are used to model signal trans...
Ulf Leser