Alternative splicing (AS) is an important and frequent step in mammalian gene expression that allows a single gene to specify multiple products, and is crucial for the regulation ...
Ofer Shai, Brendan J. Frey, Quaid Morris, Qun Pan,...
New feature selection algorithms for linear threshold functions are described which combine backward elimination with an adaptive regularization method. This makes them particular...
Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
Michael C. Ryan, Barry Zeeberg, Natasha J. Caplen,...
Background: Quantitative trait locus (QTL) mapping identifies genomic regions that likely contain genes regulating a quantitative trait. However, QTL regions may encompass tens to...
A major challenge in microarray classification and biomarker discovery is dealing with small-sample high-dimensional data where the number of genes used as features is typically o...