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BMCBI
2010
121views more  BMCBI 2010»
14 years 9 months ago
Knowledge-based annotation of small molecule binding sites in proteins
Background: The study of protein-small molecule interactions is vital for understanding protein function and for practical applications in drug discovery. To benefit from the rapi...
Ratna R. Thangudu, Manoj Tyagi, Benjamin A. Shoema...
BMCBI
2008
155views more  BMCBI 2008»
14 years 9 months ago
ComPath: comparative enzyme analysis and annotation in pathway/subsystem contexts
Background: Once a new genome is sequenced, one of the important questions is to determine the presence and absence of biological pathways. Analysis of biological pathways in a ge...
Kwangmin Choi, Sun Kim
BMCBI
2008
153views more  BMCBI 2008»
14 years 9 months ago
Estimating the size of the solution space of metabolic networks
Background: Cellular metabolism is one of the most investigated system of biological interactions. While the topological nature of individual reactions and pathways in the network...
Alfredo Braunstein, Roberto Mulet, Andrea Pagnani
BMCBI
2008
187views more  BMCBI 2008»
14 years 9 months ago
PSAT: A web tool to compare genomic neighborhoods of multiple prokaryotic genomes
Background: The conservation of gene order among prokaryotic genomes can provide valuable insight into gene function, protein interactions, or events by which genomes have evolved...
Christine Fong, Laurence Rohmer, Matthew Radey, Mi...
BMCBI
2008
116views more  BMCBI 2008»
14 years 9 months ago
Clustering exact matches of pairwise sequence alignments by weighted linear regression
Background: At intermediate stages of genome assembly projects, when a number of contigs have been generated and their validity needs to be verified, it is desirable to align thes...
Alvaro J. González, Li Liao