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BMCBI
2010
132views more  BMCBI 2010»
14 years 11 months ago
Data structures and compression algorithms for high-throughput sequencing technologies
Background: High-throughput sequencing (HTS) technologies play important roles in the life sciences by allowing the rapid parallel sequencing of very large numbers of relatively s...
Kenny Daily, Paul Rigor, Scott Christley, Xiaohui ...
BMCBI
2007
153views more  BMCBI 2007»
14 years 11 months ago
MPHASYS: a mouse phenotype analysis system
Background: Systematic, high-throughput studies of mouse phenotypes have been hampered by the inability to analyze individual animal data from a multitude of sources in an integra...
R. Brent Calder, Rudolf B. Beems, Harry van Steeg,...
BMCBI
2008
159views more  BMCBI 2008»
14 years 11 months ago
Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via log
Background: Growing interest on biological pathways has called for new statistical methods for modeling and testing a genetic pathway effect on a health outcome. The fact that gen...
Dawei Liu, Debashis Ghosh, Xihong Lin
BMCBI
2008
106views more  BMCBI 2008»
14 years 11 months ago
Ontology Design Patterns for bio-ontologies: a case study on the Cell Cycle Ontology
Background: Bio-ontologies are key elements of knowledge management in bioinformatics. Rich and rigorous bio-ontologies should represent biological knowledge with high fidelity an...
Mikel Egaña Aranguren, Erick Antezana, Mart...
BMCBI
2006
149views more  BMCBI 2006»
14 years 11 months ago
REtools: A laboratory program for restriction enzyme work: enzyme selection and reaction condition assistance
Background: Restriction enzymes are one of the everyday tools used in molecular biology. The continuously expanding panel of known restriction enzymes (several thousands) renders ...
Patrick Martin, Kim E. Boulukos, Philippe Pognonec