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BMCBI
2010
110views more  BMCBI 2010»
14 years 10 months ago
MultiRTA: A simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes
Background: The binding of peptide fragments of antigens to class II MHC is a crucial step in initiating a helper T cell immune response. The identification of such peptide epitop...
Andrew J. Bordner, Hans D. Mittelmann
BMCBI
2008
121views more  BMCBI 2008»
14 years 10 months ago
Modularization of biochemical networks based on classification of Petri net t-invariants
Background: Structural analysis of biochemical networks is a growing field in bioinformatics and systems biology. The availability of an increasing amount of biological data from ...
Eva Grafahrend-Belau, Falk Schreiber, Monika Heine...
77
Voted
BMCBI
2010
123views more  BMCBI 2010»
14 years 10 months ago
An improved classification of G-protein-coupled receptors using sequence-derived features
Background: G-protein-coupled receptors (GPCRs) play a key role in diverse physiological processes and are the targets of almost two-thirds of the marketed drugs. The 3 D structur...
Zhen-Ling Peng, Jian-Yi Yang, Xin Chen
BMCBI
2010
139views more  BMCBI 2010»
14 years 10 months ago
A global optimization algorithm for protein surface alignment
Background: A relevant problem in drug design is the comparison and recognition of protein binding sites. Binding sites recognition is generally based on geometry often combined w...
Paola Bertolazzi, Concettina Guerra, Giampaolo Liu...
BMCBI
2010
142views more  BMCBI 2010»
14 years 10 months ago
Discover Protein Complexes in Protein-Protein Interaction Networks Using Parametric Local Modularity
Background: Recent advances in proteomic technologies have enabled us to create detailed protein-protein interaction maps in multiple species and in both normal and diseased cells...
Jongkwang Kim, Kai Tan
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