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BMCBI
2006
169views more  BMCBI 2006»
15 years 2 months ago
Beyond microarrays: Finding key transcription factors controlling signal transduction pathways
Background: Massive gene expression changes in different cellular states measured by microarrays, in fact, reflect just an "echo" of real molecular processes in the cell...
Alexander E. Kel, Nico Voss, Ruy Jauregui, Olga V....
BMCBI
2006
141views more  BMCBI 2006»
15 years 2 months ago
Visual setup of logical models of signaling and regulatory networks with ProMoT
Background: The analysis of biochemical networks using a logical (Boolean) description is an important approach in Systems Biology. Recently, new methods have been proposed to ana...
Julio Saez-Rodriguez, Sebastian Mirschel, Rebecca ...
BMCBI
2006
153views more  BMCBI 2006»
15 years 2 months ago
Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments
Background: The small sample sizes often used for microarray experiments result in poor estimates of variance if each gene is considered independently. Yet accurately estimating v...
Maureen A. Sartor, Craig R. Tomlinson, Scott C. We...
BMCBI
2006
100views more  BMCBI 2006»
15 years 2 months ago
STAR: predicting recombination sites from amino acid sequence
Background: Designing novel proteins with site-directed recombination has enormous prospects. By locating effective recombination sites for swapping sequence parts, the probabilit...
Denis C. Bauer, Mikael Bodén, Ricarda Thier...
CAGD
2006
103views more  CAGD 2006»
15 years 2 months ago
The implicit structure of ridges of a smooth parametric surface
Given a smooth surface, a blue (red) ridge is a curve such that at each of its points, the maximum (minimum) principal curvature has an extremum along its curvature line. Ridges a...
Frédéric Cazals, Jean-Charles Faug&e...