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» Are There New Models of Computation
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89
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BMCBI
2010
134views more  BMCBI 2010»
15 years 17 days ago
Localizing triplet periodicity in DNA and cDNA sequences
Background: The protein-coding regions (coding exons) of a DNA sequence exhibit a triplet periodicity (TP) due to fact that coding exons contain a series of three nucleotide codon...
Liya Wang, Lincoln D. Stein
116
Voted
BMCBI
2010
165views more  BMCBI 2010»
15 years 17 days ago
Filtering, FDR and power
Background: In high-dimensional data analysis such as differential gene expression analysis, people often use filtering methods like fold-change or variance filters in an attempt ...
Maarten van Iterson, Judith M. Boer, Renée ...
125
Voted
BMCBI
2007
153views more  BMCBI 2007»
15 years 17 days ago
Estimating genealogies from linked marker data: a Bayesian approach
Background: Answers to several fundamental questions in statistical genetics would ideally require knowledge of the ancestral pedigree and of the gene flow therein. A few examples...
Dario Gasbarra, Matti Pirinen, Mikko J. Sillanp&au...
100
Voted
BMCBI
2007
97views more  BMCBI 2007»
15 years 17 days ago
Relating destabilizing regions to known functional sites in proteins
Background: Most methods for predicting functional sites in protein 3D structures, rely on information on related proteins and cannot be applied to proteins with no known relative...
Benoit H. Dessailly, Marc F. Lensink, Shoshana J. ...
101
Voted
BMCBI
2008
138views more  BMCBI 2008»
15 years 17 days ago
Using neural networks and evolutionary information in decoy discrimination for protein tertiary structure prediction
Background: We present a novel method of protein fold decoy discrimination using machine learning, more specifically using neural networks. Here, decoy discrimination is represent...
Ching-Wai Tan, David T. Jones
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