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BMCBI
2010
106views more  BMCBI 2010»
14 years 9 months ago
A computational evaluation of over-representation of regulatory motifs in the promoter regions of differentially expressed genes
Background: Observed co-expression of a group of genes is frequently attributed to co-regulation by shared transcription factors. This assumption has led to the hypothesis that pr...
Guofeng Meng, Axel Mosig, Martin Vingron
BMCBI
2008
162views more  BMCBI 2008»
14 years 9 months ago
Background correction using dinucleotide affinities improves the performance of GCRMA
Background: High-density short oligonucleotide microarrays are a primary research tool for assessing global gene expression. Background noise on microarrays comprises a significan...
Raad Z. Gharaibeh, Anthony Fodor, Cynthia Gibas
BMCBI
2008
121views more  BMCBI 2008»
14 years 9 months ago
Stability of gene contributions and identification of outliers in multivariate analysis of microarray data
Background: Multivariate ordination methods are powerful tools for the exploration of complex data structures present in microarray data. These methods have several advantages com...
Florent Baty, Daniel Jaeger, Frank Preiswerk, Mart...
BMCBI
2006
129views more  BMCBI 2006»
14 years 9 months ago
Improved alignment quality by combining evolutionary information, predicted secondary structure and self-organizing maps
Background: Protein sequence alignment is one of the basic tools in bioinformatics. Correct alignments are required for a range of tasks including the derivation of phylogenetic t...
Tomas Ohlson, Varun Aggarwal, Arne Elofsson, Rober...
SCFBM
2008
119views more  SCFBM 2008»
14 years 9 months ago
Permutation - based statistical tests for multiple hypotheses
Background: Genomics and proteomics analyses regularly involve the simultaneous test of hundreds of hypotheses, either on numerical or categorical data. To correct for the occurre...
Anyela Camargo, Francisco Azuaje, Haiying Wang, Hu...