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» Assessing the value of IS journals
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BMCBI
2010
154views more  BMCBI 2010»
14 years 9 months ago
Candidate gene prioritization by network analysis of differential expression using machine learning approaches
Background: Discovering novel disease genes is still challenging for diseases for which no prior knowledge - such as known disease genes or disease-related pathways - is available...
Daniela Nitsch, Joana P. Gonçalves, Fabian ...
BMCBI
2008
126views more  BMCBI 2008»
14 years 9 months ago
Methods for evaluating gene expression from Affymetrix microarray datasets
Background: Affymetrix high density oligonucleotide expression arrays are widely used across all fields of biological research for measuring genome-wide gene expression. An import...
Ning Jiang, Lindsey J. Leach, Xiaohua Hu, Elena Po...
BMCBI
2006
152views more  BMCBI 2006»
14 years 9 months ago
Predicting deleterious nsSNPs: an analysis of sequence and structural attributes
Background: There has been an explosion in the number of single nucleotide polymorphisms (SNPs) within public databases. In this study we focused on non-synonymous protein coding ...
Richard J. B. Dobson, Patricia B. Munroe, Mark J. ...
BMCBI
2006
171views more  BMCBI 2006»
14 years 9 months ago
The effect of oligonucleotide microarray data pre-processing on the analysis of patient-cohort studies
Background: Intensity values measured by Affymetrix microarrays have to be both normalized, to be able to compare different microarrays by removing non-biological variation, and s...
Roel G. W. Verhaak, Frank J. T. Staal, Peter J. M....
COR
2006
97views more  COR 2006»
14 years 9 months ago
Evaluating the performance of cost-based discretization versus entropy- and error-based discretization
Discretization is defined as the process that divides continuous numeric values into intervals of discrete categorical values. In this article, the concept of cost-based discretiz...
Davy Janssens, Tom Brijs, Koen Vanhoof, Geert Wets