Background: Discovering novel disease genes is still challenging for diseases for which no prior knowledge - such as known disease genes or disease-related pathways - is available...
Background: Affymetrix high density oligonucleotide expression arrays are widely used across all fields of biological research for measuring genome-wide gene expression. An import...
Ning Jiang, Lindsey J. Leach, Xiaohua Hu, Elena Po...
Background: There has been an explosion in the number of single nucleotide polymorphisms (SNPs) within public databases. In this study we focused on non-synonymous protein coding ...
Richard J. B. Dobson, Patricia B. Munroe, Mark J. ...
Background: Intensity values measured by Affymetrix microarrays have to be both normalized, to be able to compare different microarrays by removing non-biological variation, and s...
Roel G. W. Verhaak, Frank J. T. Staal, Peter J. M....
Discretization is defined as the process that divides continuous numeric values into intervals of discrete categorical values. In this article, the concept of cost-based discretiz...
Davy Janssens, Tom Brijs, Koen Vanhoof, Geert Wets