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BMCBI
2004
125views more  BMCBI 2004»
14 years 9 months ago
A functional hierarchical organization of the protein sequence space
Background: It is a major challenge of computational biology to provide a comprehensive functional classification of all known proteins. Most existing methods seek recurrent patte...
Noam Kaplan, Moriah Friedlich, Menachem Fromer, Mi...
CSB
2003
IEEE
176views Bioinformatics» more  CSB 2003»
15 years 3 months ago
3D Structural Homology Detection via Unassigned Residual Dipolar Couplings
Recognition of a protein’s fold provides valuable information about its function. While many sequence-based homology prediction methods exist, an important challenge remains: tw...
Christopher James Langmead, Bruce Randall Donald
BMCBI
2006
120views more  BMCBI 2006»
14 years 9 months ago
Integrating protein structures and precomputed genealogies in the Magnum database: Examples with cellular retinoid binding prote
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
Michael E. Bradley, Steven A. Benner
JBCB
2010
138views more  JBCB 2010»
14 years 4 months ago
Hierarchical Classification of Gene Ontology Terms Using the Gostruct Method
Protein function prediction is an active area of research in bioinformatics. And yet, transfer of annotation on the basis of sequence or structural similarity remains widely used ...
Artem Sokolov, Asa Ben-Hur
CCE
2008
14 years 9 months ago
Prediction of secondary structures of proteins using a two-stage method
Protein structure determination and prediction has been a focal research subject in life sciences due to the importance of protein structure in understanding the biological and ch...
Fadime Üney Yüksektepe, Özlem Yilma...