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BMCBI
2007
153views more  BMCBI 2007»
14 years 9 months ago
A new pairwise kernel for biological network inference with support vector machines
Background: Much recent work in bioinformatics has focused on the inference of various types of biological networks, representing gene regulation, metabolic processes, protein-pro...
Jean-Philippe Vert, Jian Qiu, William Stafford Nob...
CSB
2005
IEEE
210views Bioinformatics» more  CSB 2005»
15 years 3 months ago
Problem Solving Environment Approach to Integrating Diverse Biological Data Sources
Scientists face an ever-increasing challenge in investigating biological systems with high throughput experimental methods such as mass spectrometry and gene arrays because of the...
Eric G. Stephan, Kyle R. Klicker, Mudita Singhal, ...
JCB
2002
74views more  JCB 2002»
14 years 9 months ago
Using Substitution Matrices to Estimate Probability Distributions for Biological Sequences
Accurately estimating probabilities from observations is important for probabilistic-based approaches to problems in computational biology. In this paper we present a biologically...
Eleazar Eskin, William Stafford Noble, Yoram Singe...
IPPS
2008
IEEE
15 years 3 months ago
Supporting high performance bioinformatics flat-file data processing using indices
As an essential part of in vitro analysis, biological database query has become more and more important in the research process. A few challenges that are specific to bioinformat...
Xuan Zhang, Gagan Agrawal
BMCBI
2008
83views more  BMCBI 2008»
14 years 9 months ago
Integrative bioinformatics analysis of transcriptional regulatory programs in breast cancer cells
Background: Microarray technology has unveiled transcriptomic differences among tumors of various phenotypes, and, especially, brought great progress in molecular understanding of...
Atsushi Niida, Andrew D. Smith, Seiya Imoto, Shuic...