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BMCBI
2007
93views more  BMCBI 2007»
15 years 6 months ago
Representing default knowledge in biomedical ontologies: application to the integration of anatomy and phenotype ontologies
Background: Current efforts within the biomedical ontology community focus on achieving interoperability between various biomedical ontologies that cover a range of diverse domain...
Robert Hoehndorf, Frank Loebe, Janet Kelso, Heinri...
BMCBI
2010
142views more  BMCBI 2010»
15 years 6 months ago
Discover Protein Complexes in Protein-Protein Interaction Networks Using Parametric Local Modularity
Background: Recent advances in proteomic technologies have enabled us to create detailed protein-protein interaction maps in multiple species and in both normal and diseased cells...
Jongkwang Kim, Kai Tan
BMCBI
2008
106views more  BMCBI 2008»
15 years 6 months ago
Identification of hot-spot residues in protein-protein interactions by computational docking
Background: The study of protein-protein interactions is becoming increasingly important for biotechnological and therapeutic reasons. We can define two major areas therein: the s...
Solène Grosdidier, Juan Fernández-Re...
BMCBI
2007
139views more  BMCBI 2007»
15 years 6 months ago
Improving model predictions for RNA interference activities that use support vector machine regression by combining and filterin
Background: RNA interference (RNAi) is a naturally occurring phenomenon that results in the suppression of a target RNA sequence utilizing a variety of possible methods and pathwa...
Andrew S. Peek
BMCBI
2007
126views more  BMCBI 2007»
15 years 6 months ago
High-throughput identification of interacting protein-protein binding sites
Background: With the advent of increasing sequence and structural data, a number of methods have been proposed to locate putative protein binding sites from protein surfaces. Ther...
Jo-Lan Chung, Wei Wang, Philip E. Bourne