There are numerous mechanisms for separation of concerns at the source code level. Three mechanisms that are the focus of recent attention – metadata annotations, pointcuts and a...
Background: The identification of transcription factor binding sites is difficult since they are only a small number of nucleotides in size, resulting in large numbers of false po...
Matthew S. Hestand, Michiel van Galen, Michel P. V...
Dynamic deployment of aspects brings greater flexibility and reuse potential, but requires a proper means for scoping aspects. Scoping issues are particularly crucial in a distri...
Background: Synthetic transcription factors (STFs) promise to offer a powerful new therapeutic against Cancer, AIDS, and genetic disease. Currently, 10% of drugs are of this type,...
Stephen Winters-Hilt, Amanda Davis, Iftekhar Amin,...
Background: Transcriptional regulation is a key mechanism in the functioning of the cell, and is mostly effected through transcription factors binding to specific recognition moti...