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CSB
2005
IEEE
140views Bioinformatics» more  CSB 2005»
15 years 11 months ago
HIV Structural and Biothermodynamics Databases: a Resource for the Pharmaceutical and Biotechnology Industry
Federal agencies, academia and industries have invested heavily in the development of structural and biothermodynamic data. However, the data are still largely distributed over se...
Talapady N. Bhat, Yadu B. Tewari, Henry Rodriguez,...
CSB
2005
IEEE
182views Bioinformatics» more  CSB 2005»
15 years 11 months ago
Bacterial Whole Genome Phylogeny Using Proteome Comparison and Optimal Reversal Distance
Traditional phylogenetic tree reconstruction is based on point mutations of a single gene. This approach is hardly suitable for genomes whose genes are almost identical and hardly...
Noppadon Khiripet
CSB
2005
IEEE
110views Bioinformatics» more  CSB 2005»
15 years 11 months ago
Maximum Sequence Alignment Fails to Predict Off-targeted Gene Regulation by RNAi
We have employed various sequence alignment algorithms and scoring techniques to determine whether current computational tools accurately predict genes that will be off-targeted b...
Amanda Birmingham, Emily M. Anderson, William S. M...
CSB
2005
IEEE
116views Bioinformatics» more  CSB 2005»
15 years 11 months ago
Oscillatory dynamics in the mitogen-activated protein kinase cascade
We have used quantitative modeling of signaling networks to show that the mitogen-activated protein kinase cascade — a highly-conserved signaling network in eukaryotes — can f...
K.-H. Chiam, Vipul Bhargava, Gunaretnam Rajagopal
CSB
2005
IEEE
163views Bioinformatics» more  CSB 2005»
15 years 11 months ago
A symbolic approach to the simulation of biochemical models: application to circadian rhythms
Symbolic rewriting systems are gaining interest as tools for simulating biochemical dynamics. Compared to traditional methods based on differential equations, the symbolic approac...
Federico Fontana, Luca Bianco, Vincenzo Manca