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CSB
2003
IEEE
152views Bioinformatics» more  CSB 2003»
15 years 9 months ago
A Parallel Genetic Algorithm for Physical Mapping of Chromosomes
Physical map reconstruction in the presence of errors is a central problem in genetics of high computational complexity. A parallel genetic algorithm for a maximum likelihood esti...
Suchendra M. Bhandarkar, Jinling Huang, Jonathan A...
CSB
2003
IEEE
110views Bioinformatics» more  CSB 2003»
15 years 9 months ago
Prokaryote Phylogeny without Sequence Alignment: From Avoidance Signature to Composition Distance
A new and essentially simple method to reconstruct prokaryotic phylogenetic trees from their complete genome data without using sequence alignment is proposed. It is based on the ...
Bailin Hao, Ji Qi
CSB
2003
IEEE
153views Bioinformatics» more  CSB 2003»
15 years 9 months ago
Combining Microarrays and Biological Knowledge for Estimating Gene Networks via Bayesian Networks
We propose a statistical method for estimating a gene network based on Bayesian networks from microarray gene expression data together with biological knowledge including protein-...
Seiya Imoto, Tomoyuki Higuchi, Takao Goto, Kousuke...
CSB
2003
IEEE
15 years 9 months ago
Estimating Recombination Rate Distribution by Optimal Quantization
We obtain recombination rate distribution functions for all human chromosomes using an optimal quantization method. This non-parametric method allows us to control over-/under-fi...
Mingzhou Song, Stéphane Boissinot, Robert M...
CSB
2003
IEEE
111views Bioinformatics» more  CSB 2003»
15 years 9 months ago
A Contradiction-Based Framework for Testing Gene Regulation Hypotheses
We have developed a mathematical framework for representing and testing hypotheses about gene, protein, and signaling molecule interactions. It takes a hierarchical, contradiction...
Steve Racunas, Nigam Shah, Nina V. Fedoroff