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143
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BMCBI
2008
119views more  BMCBI 2008»
15 years 3 months ago
A new method for 2D gel spot alignment: application to the analysis of large sample sets in clinical proteomics
Background: In current comparative proteomics studies, the large number of images generated by 2D gels is currently compared using spot matching algorithms. Unfortunately, differe...
Sabine Pérès, Laurence Molina, Nicol...
130
Voted
BMCBI
2008
117views more  BMCBI 2008»
15 years 3 months ago
An iterative block-shifting approach to retention time alignment that preserves the shape and area of gas chromatography-mass sp
Background: Metabolomics, petroleum and biodiesel chemistry, biomarker discovery, and other fields which rely on high-resolution profiling of complex chemical mixtures generate da...
Minho Chae, Robert J. Shmookler Reis, John J. Thad...
170
Voted
BMCBI
2008
138views more  BMCBI 2008»
15 years 3 months ago
SynechoNET: integrated protein-protein interaction database of a model cyanobacterium Synechocystis sp. PCC 6803
Background: Cyanobacteria are model organisms for studying photosynthesis, carbon and nitrogen assimilation, evolution of plant plastids, and adaptability to environmental stresse...
Woo-Yeon Kim, Sungsoo Kang, Byoung-Chul Kim, Jeehy...
135
Voted
BIOINFORMATICS
2006
92views more  BIOINFORMATICS 2006»
15 years 3 months ago
What should be expected from feature selection in small-sample settings
Motivation: High-throughput technologies for rapid measurement of vast numbers of biological variables offer the potential for highly discriminatory diagnosis and prognosis; howev...
Chao Sima, Edward R. Dougherty
146
Voted
BMCBI
2006
120views more  BMCBI 2006»
15 years 3 months ago
Integrating protein structures and precomputed genealogies in the Magnum database: Examples with cellular retinoid binding prote
Background: When accurate models for the divergent evolution of protein sequences are integrated with complementary biological information, such as folded protein structures, anal...
Michael E. Bradley, Steven A. Benner
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