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159
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BMCBI
2010
123views more  BMCBI 2010»
14 years 10 months ago
Predicting conserved protein motifs with Sub-HMMs
Background: Profile HMMs (hidden Markov models) provide effective methods for modeling the conserved regions of protein families. A limitation of the resulting domain models is th...
Kevin Horan, Christian R. Shelton, Thomas Girke
150
Voted
BMCBI
2011
14 years 10 months ago
Context-dependent transcriptional regulations between signal transduction pathways
Background: Cells coordinate their metabolism, proliferation, and cellular communication according to environmental cues through signal transduction. Because signal transduction h...
Sohyun Hwang, Sangwoo Kim, Heesung Shin, Doheon Le...
148
Voted
BMCBI
2011
14 years 10 months ago
Identifying hypermethylated CpG islands using a quantile regression model
Background: DNA methylation has been shown to play an important role in the silencing of tumor suppressor genes in various tumor types. In order to have a system-wide understandin...
Shuying Sun, Zhengyi Chen, Pearlly Yan, Yi-Wen Hua...
138
Voted
BMCBI
2011
14 years 10 months ago
MRCQuant- an accurate LC/MS relative isotopic quantification algorithm on TOF instruments
Background: Relative isotope abundance quantification, which can be used for peptide identification and differential peptide quantification, plays an important role in liquid chro...
William H. Haskins, Konstantinos Petritis, Jianqiu...
151
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NAR
2010
281views more  NAR 2010»
14 years 10 months ago
PDBselect 1992-2009 and PDBfilter-select
PDBselect (http://bioinfo.tg.fh-giessen.de/pdb select/) is a list of representative protein chains with low mutual sequence identity selected from the protein data bank (PDB) to e...
Sven Griep, Uwe Hobohm
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