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BMCBI
2011
14 years 4 months ago
A theoretical entropy score as a single value to express inhibitor selectivity
Background: Designing maximally selective ligands that act on individual targets is the dominant paradigm in drug discovery. Poor selectivity can underlie toxicity and side effect...
Joost C. M. Uitdehaag, Guido J. R. Zaman
ASPLOS
2011
ACM
14 years 1 months ago
MemScale: active low-power modes for main memory
Main memory is responsible for a large and increasing fraction of the energy consumed by servers. Prior work has focused on exploiting DRAM low-power states to conserve energy. Ho...
Qingyuan Deng, David Meisner, Luiz E. Ramos, Thoma...
IWMM
2011
Springer
206views Hardware» more  IWMM 2011»
14 years 19 days ago
A comprehensive evaluation of object scanning techniques
At the heart of all garbage collectors lies the process of identifying and processing reference fields within an object. Despite its key role, and evidence of many different impl...
Robin Garner, Stephen M. Blackburn, Daniel Frampto...
SIGMOD
2011
ACM
158views Database» more  SIGMOD 2011»
14 years 16 days ago
Workload-aware database monitoring and consolidation
In most enterprises, databases are deployed on dedicated database servers. Often, these servers are underutilized much of the time. For example, in traces from almost 200 producti...
Carlo Curino, Evan P. C. Jones, Samuel Madden, Har...
ASPLOS
2012
ACM
13 years 5 months ago
Clearing the clouds: a study of emerging scale-out workloads on modern hardware
Emerging scale-out workloads require extensive amounts of computational resources. However, data centers using modern server hardware face physical constraints in space and power,...
Michael Ferdman, Almutaz Adileh, Yusuf Onur Ko&cce...