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BMCBI
2008
106views more  BMCBI 2008»
15 years 6 months ago
SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi,
Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
Michael C. Ryan, Barry Zeeberg, Natasha J. Caplen,...
BMCBI
2007
99views more  BMCBI 2007»
15 years 6 months ago
Orthogonal projections to latent structures as a strategy for microarray data normalization
Background: During generation of microarray data, various forms of systematic biases are frequently introduced which limits accuracy and precision of the results. In order to prop...
Max Bylesjö, Daniel Eriksson, Andreas Sjö...
BMCBI
2010
154views more  BMCBI 2010»
15 years 6 months ago
Candidate gene prioritization by network analysis of differential expression using machine learning approaches
Background: Discovering novel disease genes is still challenging for diseases for which no prior knowledge - such as known disease genes or disease-related pathways - is available...
Daniela Nitsch, Joana P. Gonçalves, Fabian ...
BMCBI
2008
121views more  BMCBI 2008»
15 years 6 months ago
OntoDas - a tool for facilitating the construction of complex queries to the Gene Ontology
Background: Ontologies such as the Gene Ontology can enable the construction of complex queries over biological information in a conceptual way, however existing systems to do thi...
Kieran O'Neill, Alexander García Castro, An...
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BMCBI
2008
214views more  BMCBI 2008»
15 years 6 months ago
Accelerating String Set Matching in FPGA Hardware for Bioinformatics Research
Background: This paper describes techniques for accelerating the performance of the string set matching problem with particular emphasis on applications in computational proteomic...
Yoginder S. Dandass, Shane C. Burgess, Mark Lawren...
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