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BMCBI
2007
265views more  BMCBI 2007»
15 years 4 months ago
Large scale clustering of protein sequences with FORCE -A layout based heuristic for weighted cluster editing
Background: Detecting groups of functionally related proteins from their amino acid sequence alone has been a long-standing challenge in computational genome research. Several clu...
Tobias Wittkop, Jan Baumbach, Francisco P. Lobo, S...
BMCBI
2008
117views more  BMCBI 2008»
15 years 4 months ago
A probabilistic framework to predict protein function from interaction data integrated with semantic knowledge
Background: The functional characterization of newly discovered proteins has been a challenge in the post-genomic era. Protein-protein interactions provide insights into the funct...
Young-Rae Cho, Lei Shi, Murali Ramanathan, Aidong ...
BMCBI
2007
216views more  BMCBI 2007»
15 years 4 months ago
A replica exchange Monte Carlo algorithm for protein folding in the HP model
Background: The ab initio protein folding problem consists of predicting protein tertiary structure from a given amino acid sequence by minimizing an energy function; it is one of...
Chris Thachuk, Alena Shmygelska, Holger H. Hoos
BMCBI
2007
154views more  BMCBI 2007»
15 years 4 months ago
Inferring biological networks with output kernel trees
Background: Elucidating biological networks between proteins appears nowadays as one of the most important challenges in systems biology. Computational approaches to this problem ...
Pierre Geurts, Nizar Touleimat, Marie Dutreix, Flo...
IJSEKE
2006
99views more  IJSEKE 2006»
15 years 4 months ago
Weaving Deployment Aspects into Domain-specific Models
pecific models increase the level of abstraction used to develop large-scale component-based systems. Model-driven development (MDD) approaches (e.g., ModelIntegrated Computing and...
Krishnakumar Balasubramanian, Aniruddha S. Gokhale...
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