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» Challenges for knowledge discovery in biology
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119
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BMCBI
2005
106views more  BMCBI 2005»
15 years 12 days ago
A multistep bioinformatic approach detects putative regulatory elements in gene promoters
Background: Searching for approximate patterns in large promoter sequences frequently produces an exceedingly high numbers of results. Our aim was to exploit biological knowledge ...
Stefania Bortoluzzi, Alessandro Coppe, Andrea Biso...
108
Voted
BMCBI
2005
150views more  BMCBI 2005»
15 years 12 days ago
Discover protein sequence signatures from protein-protein interaction data
Background: The development of high-throughput technologies such as yeast two-hybrid systems and mass spectrometry technologies has made it possible to generate large protein-prot...
Jianwen Fang, Ryan J. Haasl, Yinghua Dong, Gerald ...
126
Voted
BMCBI
2008
141views more  BMCBI 2008»
15 years 19 days ago
Ontology-guided data preparation for discovering genotype-phenotype relationships
Complexity of post-genomic data and multiplicity of mining strategies are two limits to Knowledge Discovery in Databases (KDD) in life sciences. Because they provide a semantic fr...
Adrien Coulet, Malika Smaïl-Tabbone, Pascale ...
BMCBI
2006
141views more  BMCBI 2006»
15 years 17 days ago
The use of concept maps during knowledge elicitation in ontology development processes - the nutrigenomics use case
Background: Incorporation of ontologies into annotations has enabled 'semantic integration' of complex data, making explicit the knowledge within a certain field. One of...
Alexander García Castro, Philippe Rocca-Ser...
100
Voted
CIBB
2008
15 years 2 months ago
Curating a Large-Scale Regulatory Network by Evaluating Its Consistency with Expression Datasets
Abstract. The analysis of large-scale regulatory models using data issued from genome-scale high-throughput experimental techniques is an actual challenge in the systems biology fi...
Carito Guziolowski, Jeremy Gruel, Ovidiu Radulescu...