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» Challenges for knowledge discovery in biology
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BMCBI
2005
117views more  BMCBI 2005»
14 years 9 months ago
An evaluation of GO annotation retrieval for BioCreAtIvE and GOA
Background: The Gene Ontology Annotation (GOA) database http://www.ebi.ac.uk/GOA aims to provide high-quality supplementary GO annotation to proteins in the UniProt Knowledgebase....
Evelyn Camon, Daniel Barrell, Emily Dimmer, Vivian...
BMCBI
2011
14 years 4 months ago
Investigating the effect of paralogs on microarray gene-set analysis
Background: In order to interpret the results obtained from a microarray experiment, researchers often shift focus from analysis of individual differentially expressed genes to an...
Andre J. Faure, Cathal Seoighe, Nicola J. Mulder
WWW
2007
ACM
15 years 10 months ago
BOWiki - a Collaborative Annotation and Ontology Curation Framework
As the amount of data being generated in biology has increased, a major challenge has been how to store and represent this data in a way that makes it easily accessible to researc...
Michael Backhaus, Janet Kelso, Joshua Bacher, Hein...
CSB
2003
IEEE
15 years 2 months ago
LOGOS: a modular Bayesian model for de novo motif detection
The complexity of the global organization and internal structures of motifs in higher eukaryotic organisms raises significant challenges for motif detection techniques. To achiev...
Eric P. Xing, Wei Wu, Michael I. Jordan, Richard M...
BMCBI
2007
247views more  BMCBI 2007»
14 years 9 months ago
A survey of DNA motif finding algorithms
Background: Unraveling the mechanisms that regulate gene expression is a major challenge in biology. An important task in this challenge is to identify regulatory elements, especi...
Modan K. Das, Ho-Kwok Dai