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» Challenges for knowledge discovery in biology
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EDBT
2009
ACM
208views Database» more  EDBT 2009»
15 years 4 months ago
Flexible and efficient querying and ranking on hyperlinked data sources
There has been an explosion of hyperlinked data in many domains, e.g., the biological Web. Expressive query languages and effective ranking techniques are required to convert this...
Ramakrishna Varadarajan, Vagelis Hristidis, Louiqa...
RECOMB
2010
Springer
14 years 11 months ago
Algorithms for Detecting Significantly Mutated Pathways in Cancer
Abstract. Recent genome sequencing studies have shown that the somatic mutations that drive cancer development are distributed across a large number of genes. This mutational heter...
Fabio Vandin, Eli Upfal, Benjamin J. Raphael
BIODATAMINING
2008
178views more  BIODATAMINING 2008»
14 years 9 months ago
Clustering-based approaches to SAGE data mining
Serial analysis of gene expression (SAGE) is one of the most powerful tools for global gene expression profiling. It has led to several biological discoveries and biomedical appli...
Haiying Wang, Huiru Zheng, Francisco Azuaje
BMCBI
2010
138views more  BMCBI 2010»
14 years 9 months ago
A model-independent approach to infer hierarchical codon substitution dynamics
Background: Codon substitution constitutes a fundamental process in molecular biology that has been studied extensively. However, prior studies rely on various assumptions, e.g. r...
Olof Görnerup, Martin Nilsson Jacobi
GECCO
2007
Springer
258views Optimization» more  GECCO 2007»
15 years 1 months ago
TFBS identification by position- and consensus-led genetic algorithm with local filtering
Identification of Transcription Factor Binding Site (TFBS) motifs in multiple DNA upstream sequences is important in understanding the mechanism of gene regulation. This identific...
Tak-Ming Chan, Kwong-Sak Leung, Kin-Hong Lee