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» Challenges for knowledge discovery in biology
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BMCBI
2010
202views more  BMCBI 2010»
14 years 9 months ago
NeMo: Network Module identification in Cytoscape
Background: As the size of the known human interactome grows, biologists increasingly rely on computational tools to identify patterns that represent protein complexes and pathway...
Corban G. Rivera, Rachit Vakil, Joel S. Bader
BMCBI
2008
106views more  BMCBI 2008»
14 years 9 months ago
SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi,
Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
Michael C. Ryan, Barry Zeeberg, Natasha J. Caplen,...
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BMCBI
2006
116views more  BMCBI 2006»
14 years 9 months ago
Optimized mixed Markov models for motif identification
Background: Identifying functional elements, such as transcriptional factor binding sites, is a fundamental step in reconstructing gene regulatory networks and remains a challengi...
Weichun Huang, David M. Umbach, Uwe Ohler, Leping ...
IPM
2007
123views more  IPM 2007»
14 years 9 months ago
Generating gene summaries from biomedical literature: A study of semi-structured summarization
Most knowledge accumulated through scientific discoveries in genomics and related biomedical disciplines is buried in the vast amount of biomedical literature. Since understandin...
Xu Ling, Jing Jiang, Xin He, Qiaozhu Mei, Chengxia...
AVI
2010
14 years 11 months ago
Advanced visual analytics interfaces
Advanced visual interfaces, like the ones found in informaualization, intend to offer a view on abstract data spaces to enable users to make sense of them. By mapping data to visu...
Daniel A. Keim, Peter Bak, Enrico Bertini, Daniela...