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» Challenges of sequencing human genomes
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BMCBI
2010
155views more  BMCBI 2010»
14 years 12 months ago
BISMA - Fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences
Background: Bisulfite sequencing is a popular method to analyze DNA methylation patterns at high resolution. A region of interest is targeted by PCR and about 20-50 subcloned DNA ...
Christian Rohde, Yingying Zhang, Richard Reinhardt...
JACM
2002
94views more  JACM 2002»
14 years 11 months ago
The greedy path-merging algorithm for contig scaffolding
Given a collection of contigs and mate-pairs. The Contig Scaffolding Problem is to order and orientate the given contigs in a manner that is consistent with as many mate-pairs as p...
Daniel H. Huson, Knut Reinert, Eugene W. Myers
DMTCS
2003
99views Mathematics» more  DMTCS 2003»
15 years 1 months ago
Combinatorial Problems Arising in SNP and Haplotype Analysis
It is widely anticipated that the study of variation in the human genome will provide a means of predicting risk of a variety of complex diseases. This paper presents a number of a...
Bjarni V. Halldórsson, Vineet Bafna, Nathan...
GCB
2006
Springer
140views Biometrics» more  GCB 2006»
15 years 3 months ago
PALMA: Perfect Alignments using Large Margin Algorithms
: Despite many years of research on how to properly align sequences in the presence of sequencing errors, alternative splicing and micro-exons, the correct alignment of mRNA sequen...
Gunnar Rätsch, Bettina Hepp, Uta Schulze, Che...
PRIB
2009
Springer
113views Bioinformatics» more  PRIB 2009»
15 years 6 months ago
c-GAMMA: Comparative Genome Analysis of Molecular Markers
Discovery of molecular markers for efficient identification of living organisms remains a challenge of high interest. The diversity of species can now be observed in details with ...
Pierre Peterlongo, Jacques Nicolas, Dominique Lave...